Case Study

A novel mouse model using optical imaging to detect on-target- off-tumor CAR-T cell toxicity

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CAR T therapy has achieved tremendous success in treating blood malignancies, however treating solid tumors with this therapy has proven to be challenging due to several factors such as on-tumor, off-tumor toxicity.

Read this case study where researchers from University of Pennsylvania created a mouse model that expresses tumor associated antigens in normal tissue to study off-tumor CAR-T cell toxicity. These studies used optical imaging on the IVIS® platform to longitudinally monitor off-tumor antigen expression, tumor progression, and CAR-T cell trafficking in live animals.

For research use only. Not for use in diagnostic procedures.

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A novel mouse model using optical imaging to detect on-target- off-tumor CAR-T cell toxicity

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